Principal Product Manager, Science

The Team

CZI supports the science and technology that will make it possible to help scientists cure, prevent, or manage all diseases by the end of this century. While this may seem like an audacious goal, in the last 100 years, biomedical science has made tremendous strides in understanding biological systems, advancing human health, and treating disease. 

Achieving our mission will only be possible if scientists are able to better understand human biology. To that end, we have identified four grand challenges that will unlock the mysteries of the cell and how cells interact within systems — paving the way for new discoveries that will change medicine in the decades that follow:

• Building an AI-based virtual cell model to predict and understand cellular behavior
• Developing state-of-the-art imaging systems to observe living cells in action
• Instrumenting tissues to better understand inflammation, a key driver of many diseases
• Engineering and harnessing the immune system for early detection, prevention, and treatment of disease

CZI’s work in science includes grantmaking programs, open-source software development, and close collaboration with the Chan Zuckerberg Biohub Network. The CZ Biohub Network includes the San Francisco, Chicago, and New York Biohubs as well as the Chan Zuckerberg Imaging Institute. CZI also collaborates with institutional partners like the Kempner Institute for the Study of Natural & Artificial Intelligence at Harvard University. Join us in accelerating science.

The Opportunity

We are seeking a Principal Product Manager with deep expertise in biology to lead the development of AI-powered workflows that accelerate scientific discovery. In this role, you will partner with scientists to translate research needs into scalable products that integrate AI models into real-world experimental workflows.

As part of the Science Technology (SciTech) team, you will shape products that empower computational and experimental researchers to use AI for in silico experimentation, hypothesis generation, data interpretation, and biological modeling. You will work across disciplines to identify high-impact opportunities where AI can meaningfully accelerate scientific progress, and translate them into impactful, scalable tools integrated within the CZI Virtual Cells Platform.

Examples include:

• Multi-modal workflows for users to run inference on models with their own data (e.g., annotation, healthy vs. disease comparisons).
• Tools to run and visualize in silico experiments using AI models, e.g. simulate how specific gene knockouts affect cell behavior in a virtual T-cell model.
• A visualization library for exploring multi-dimensional biological imaging data.
• Enabling the use of AI agents that assist experimental biologists in designing experiments by integrating prior datasets, model predictions, and literature insights.

What You'll Do

• Define and drive the product strategy for AI-powered biological workflows to enable in silico experimentation.
• Collaborate with scientific partners to deeply understand research needs and translate them into high-impact model applications, bridging the gap between cutting-edge AI research and its real-world application in biological discovery.
• Lead the development and deployment of workflows that bring cutting-edge models into biologists’ research practices.
• Partner with AI PMs, ML researchers, engineers, and designers to integrate models into intuitive, impactful tools.
• Help shape model roadmaps and value propositions by working closely with CZI’s ML researchers.
• Collate and translate the needs of the CZ Imaging research teams into a platform strategy.
• Serve as the voice of the biologist in product development, ensuring tools align with experimental research needs.

What You'll Bring

• 12+ years of product management or related experience, with a strong background in genomics, imaging, immunology, or other relevant biological domains.
• Experience in computational biology and/or applying AI models for in silico workflows.
• Proven track record of partnering with scientists to develop domain-specific tools or platforms.
• Ability to translate complex biological research needs into product requirements and workflows.
• Demonstrated ability to work collaboratively with interdisciplinary teams and external partners.
• Excellent communication skills, able to bridge biology and technology for diverse audiences.
• Passion for CZI’s mission and a desire to drive scientific progress through technology.
• (nice to have) Experience working with cutting-edge biological imaging technology.

Compensation

The Redwood City, CA base pay range for a new hire in this role is $241,000 - $331,100. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. 

Better Together

As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• CZI provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs.
• CZI Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving to the Bay Area
• And more!

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

Explore our work modes, benefits, and interview process at www.chanzuckerberg.com/careers.

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